Holmium Laser Enucleation of the Prostate (HoLEP) is a safe and effective BPH treatment option for prostates of all sizes.   

The holmium laser penetrates just enough to precisely and quickly vaporize tissue without causing deeper thermal injury, coagulation necrosis or collateral damage.

HoLEP involves enucleation of the median lobe, followed by the lateral lobes. The lobes are placed into the bladder for removal by morcellation. HoLEP offers comparable clinical outcomes with fewer complications as compared to TURP or Open Prostatectomy and lower re-operation rates as compared to TURP.


  • Physicians experience

    HoLEP results are comparable to TURP and Open Prostatectomy

    HoLEP Advantages as Compared with TURP1,2,3,4,5,6

    • Appropriate for outpatient setting
    • Suitable for any size of prostate
    • Lower perioperative morbidity
    • Better bladder outlet obstruction relief
    • Can be performed on anticoagulated patients
    • No TUR syndrome
    • Equivalent reoperation rates
    • Equivalent durability

    HoLEP Advantages as Compared with Open Prostatectomy 1,2,3,4,5,6

    • Similar AUA symptom scores and Qmax
    • Minimally invasive
    • Shorter catheter duration
    • Shorter hospital stay
    • No blood transfusions required
  • Patient experience

  • Clinical Publications

    Latest clinical publications show HoLEP is durable at 10 years. 

    1 QOL, Qmax ml/s and IPSS outcomes at 10 years are comparable to outcomes at 1 year

    HoLEP has fewer complicationsand lower re-operation rate1,2,3,7,8,9,10

    HoLEP and HoLAP are backed by strong clinical evidence 

    HoLAP/HoLEP are the most studied laser BPH treatments with the highest number ofpublished randomized controlled trials

  • References

    1. Holmium Laser Enucleation of the Prostate: Long-Term Durability of Clinical Outcomes and Complication rates During 10 Years of Followup, Hazem M. Elmansy,Mostafa M. Elhilali, Ahmed Kotb. J Urol (Nov 2011) Vol 186, 1972-1976.
    2. Holmium Laser Enucleation of the Prostate Versus Open Prostatectomy for Prostates Greater Than 100 Grams; 5-Year Follow-up Results of aRandomized Clinical Trial, Kuntz RM, Lehrich K, Ahvai S. Eur Urol 2008 Apr:53:160-168
    3. A Randomized Trial Comparing Holmium Laser Enucleation of the Prostate with Transurethral Resection of the Prostate for the Treatment ofBladder Outlet Obstruction, Secondary to Benign Prostatic Hyperplasia in Large Glands (40 to 200 grams), Tan AH, Gilling P, et al. J Urol (Oct. 2003)170:1270-1274
    4. Randomized Comparison of Transurethral Electroresection and Holmium: YAG Laser Vaporization for Symptomatic Benign Prostatic Hyperplasia,Mottet N, Anidjar J, et al. J Endourol 1999 13:127-130
    5. Holmium Laser Enucleation of the Prostate for Prostates of >125mL., Matlaga BR, Lingeman JE, et al. BJU International, 97:81-84, Jan 2006.
    6. Holmium Laser Bladder Neck Incision vs. Holmium Enucleation of the Prostate as Outpatient Procedures for Prostates Less Than 40 Grams: ARandomized Trial, Aho, TF, Gilling P, et al. J Urol, 174, 210-214, Jul 2005
    7. KTP Laser versus transurethral resection: early results of a randomized trial Bouchier-Hayes DM, Anderson P, et al. J Endourol 2006 Vol 20 (8):580-585
    8. Photoselective potassium titanyl phosphate (KTP) laser vaporization vs. transurethral resection of the prostate for prostates larger than 70mL: a short-term prospectiverandomized trial Horasanli K, Silay M, et al. J Urol 2008 71:247-251
    9. The Diode Laser: A Novel Side-Firing Approach for Laser Vaporisation of the Human Prostate – Immediate Efficacy and 1 – Year Follow- Up Seitz M., Sroka, R., et al. EurUrol 2007 June; 52 1717-1772
    10. Thulium Laser versus Standard Transurethral Resection of the Prostate: A Randomized Trial Xia, S. et al. European Urology 2006 Vol 53 382-3901

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